Noninvasive Neuromodulation Goes Deep

Noninvasive Neuromodulation Goes Deep.

Modulating deep regions of the brain with noninvasive technology has challenged researchers for decades. In a new study, Grossman et al. leverage the emergence of a slowly oscillating "beat" from intersecting high-frequency electric fields to stimulate deep brain regions, opening a frontier in the biophysics and technology of brain stimulation.

In vitro evolution goes deep.

A pproximately 20 years ago when one of the authors of this commentary was a postdoctoral fellow in Bob Sauer’s laboratory at Massachusetts Institute of Technology, an extremely energetic individual (the author in question was not one of these) could run three sequencing gels in one day, and thus potentially obtain 72 sequence reads of a few hundred bases each (in practice, unfortunately, one n...

Noninvasive neuromodulation with ultrasound? A continuum mechanics hypothesis.

Deep brain stimulation and vagal nerve stimulation are therapeutically effective in treating some neurological diseases and psychiatric disorders. Optogenetic-based neurostimulation approaches are capable of activating individual synapses and yield the highest spatial control over brain circuit activity. Both electrical and light-based neurostimulation methods require intrusive procedures such ...

Noninvasive Neuromodulation Methods in the Treatment of Chronic Pain

Seasonal Biology: Avian Photoreception Goes Deep

The avian hypothalamus senses light directly, allowing endocrine physiology to synchronise to seasonal day-length changes. New data implicate the photopigment VA-opsin in this deep brain photoreception.